This tremendously complex disease that is myotonic dystrophy may be narrowing for a cure in the next few years. The root cause is known. There are a number of models or ways that the disease can be fixed. One approach that of an antisense nucleotide has been tried on a mouse that had myotonic dystrophy and it worked. (Isis pharmaceuticals). Tomorrow at the meeting below Dr. Richard Moxley one of the foremost researchers into myotonic dystrophy will be speaking about “Curing Myotonic Dystrophy”. It’s a step in the right direction and an indication that there might possibly be a cure coming in the future…
2012 MSG Scientific Annual Meeting Clinical Trial Design and Biomarkers in Neuromuscular Disease Beaver Hollow Conference Center, Java Center, NY September 27 – 29, 2012
8:30 PM Keynote Speaker: Richard Moxley (University of Rochester) Curing Myotonic Dystrophy Fireside Room
To anyone affected with this disease, Hope is there and perhaps not too far out!
Congenital Myotonic Dystrophy is present at the birth of the Infant. A mother may notice excessive amniotic fluid or polyhydraminos. The mother may also notice less fetal movements than is normal. The baby is born sometimes prematurely. It is a disease that will cause multiple symptoms in the baby. The link to the baby is the mother in almost all cases. For instance, out of 118 cases only 2 cases had any incident that the father was the carrier. However, Paternal transmission (by the father) is documented. (Paternal Transmission of Congenital Myotonic Dystrophy J Med Genet 1994;31518-520) It seems as though the mother somehow causes the disease in the severe form. Some researchers postulate that there does not seem to be a genetic reason for the severe problems that may be caused by the disorder. It may be that the Myotonic Dystrophy in the mother somehow causes the severe congenital form.
In Sweden there is identified two types of congenital myotonic dystrophy, severe and moderate. In the severe type there is a life threatening condition at birth. This seems to be associated with male children more than female. With the moderate type of congenital myotonic dystrophy there is no life threatening condition birth. This information is contained in several studies as well as confirmed by by Ekstrom at a recent conference. The severe type will generally have more symptoms and more severe symptoms of the disease.
Congential as well as juvenile and adolenscent myotonic dystrophy are hard to diagnosis and identify. Part of the reason for this is that the medical profession does not recongnize this disease as a separate and distinct disease. They symtoms of congenital myotonic dystrophy are separate and distinct from mytonic dystrophy type 1. Thus, its hard for parents to identify the disease that their child may have. For example mental retardation and autism spectrum disorder are not symtoms of myotonic dystrophy. But they are symtoms of the congential or juvenile forms of the disease.
Myotonic Dystrophy Symptoms: People with Myotonic Dystrophy may exhibit more or more of the following symptoms which many vary in how severe they are. Some people will have many of the symptoms others much fewer. There is a generally relationship between the number of repeats of the CTG on Chromosome 19 and the severity of the disease. There are two symtomology paths with DM. One is the standard or adult onset path. The other is the Juvenile or congenital path. See the Congenital and Juvenile sections for this information for the standard Myotonic Dystrophy Type 1
Polyhydraminos (Excess amniotic fluid during pregnancy)
This symptom is present during pregnancy. Usually amniotic fluid is swallowed by the baby and expelled through the umbilical cord. This does not occur and fluid builds up in the mother and can trigger premature birth. Careful monitoring by a doctor is necessary.
The bowel and gastrointestinal tract are affected by the disease. This causes constipation and excessive time on the toilet.